Nonapeptide-1

What is Nonapeptide-1?

Nonapeptide-1, also known as Melanostatine™, is a synthetic biomimetic peptide that mimics a portion of the α-MSH (alpha-Melanocyte Stimulating Hormone). Designed to reduce melanin overproduction, it works by blocking MC1-R receptors on melanocytes, helping to diminish dark spots and even out skin tone—making it an ideal skin brightening peptide for modern cosmetic formulations.

Key Benefits of Nonapeptide-1

Nonapeptide-1 for Skin Brightening

By selectively inhibiting melanin synthesis, Nonapeptide-1 promotes a more radiant, luminous complexion without disrupting natural skin function.

Nonapeptide-1 Pigment Reduction Peptide

This peptide acts as a melanogenesis regulator, effectively reducing pigmentation caused by UV damage, melasma, freckles, and PIH (post-inflammatory hyperpigmentation).

Nonapeptide-1 vs Hydroquinone

Unlike hydroquinone, Nonapeptide-1 offers a non-toxic, non-irritating solution for skin lightening. It preserves melanocyte health while preventing excess pigment, making it safer for long-term use across all skin types.

Nonapeptide-1 Dark Spot Cream Benefits

Perfect for formulating dark spot correctors and pigmentation-reducing creams, this ingredient visibly reduces sunspots and discoloration within 28 days of regular use.

How It Works

MC1-R Receptor Antagonism

Nonapeptide-1 competes with α-MSH at melanocyte receptors (MC1-R), blocking signal transduction and limiting melanin production at the source.

Tyrosinase Inhibition

By reducing MC1-R activation, it indirectly suppresses tyrosinase activity, a key enzyme in the pigment production pathway, leading to lighter skin with fewer dark spots.

Functions

• Skin Whitening Agent – Lightens complexion without cytotoxicity
• Skin Conditioning – Smooths texture and tone
• Hair Conditioning – Supports healthy scalp environments in hair care
• Post-UV Care – Helps reverse pigment changes caused by sun exposure

Applications

Use Nonapeptide-1 in:

• Dark spot creams and serums
• Non-toxic skin brightening treatments
• Melasma and sunspot-reduction products
• Post-acne hyperpigmentation skincare
• Hair care serums for scalp support

Technical Specifications

• INCI: Nonapeptide-1
• Synonym: Melanostatine™
• CAS No.: 158563-45-2
• FDA UNII: 64W45420K5
• Solubility: Water-soluble
• Suggested Usage: 0.1–2.5%

Where to Buy Nonapeptide-1 Peptide?

Looking for where to buy Nonapeptide-1 peptide? We provide high-purity, cosmetic-grade Nonapeptide-1 raw material for research, formulation, and private label skincare product development.

Why Choose Nonapeptide-1?

Nonapeptide-1 offers a safe, effective alternative to harsh depigmenting agents like hydroquinone. With its smart mechanism targeting melanin at the source, it brightens skin, fades dark spots, and evens tone—without irritation or damage.

Make it your go-to pigment reduction peptide for next-generation dark spot correction and skin brightening products.