COG133, ApoE Mimetic Peptide

COG133 ApoE Mimetic Peptide – Neuroprotective & Anti-Inflammatory Agent

COG133 is a synthetic ApoE mimetic peptide derived from the receptor-binding region of apolipoprotein E. It exhibits potent anti-inflammatory, neuroprotective, and cognitive-supportive effects, making it a key research peptide in neurodegenerative disease models and neuroimmune regulation.

COG133 Peptide for Cognitive Health

COG133 acts via the low-density lipoprotein receptor-related protein (LRP) pathway and demonstrates promising applications in neurobiology, especially:

• Suppressing neuroinflammation
• Reducing demyelination
• Supporting cognitive resilience

In studies on experimental autoimmune encephalomyelitis (EAE)—a model of multiple sclerosis—COG133 significantly reduced clinical symptoms and spinal cord inflammation. This highlights its relevance for cognitive health and neuroinflammatory research.

COG133 Anti-Inflammatory Effects

• Modulates CNS inflammation by targeting immune cell infiltration
• Reduces pro-inflammatory cytokines, helping preserve myelin integrity
• Shows activity as a non-competitive α7 nicotinic acetylcholine receptor antagonist with an IC₅₀ of 445 nM
• Useful in inflammation-related neurological studies

COG133 vs COG112 Peptide Comparison

While both are derived from ApoE peptides, COG133 and COG112 differ in design and application:

• COG133: LRP-dependent pathway, potent anti-inflammatory and cognitive protection
• COG112: COG133 + penetratin sequence for improved BBB permeability
  For applications not requiring direct CNS delivery, COG133 peptide offers a cleaner, focused mechanism of action.

Technical Specifications

• Peptide Name: COG133
• Sequence: Ac-LRVRLASHLRKLRKRLL-NH₂
• Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉
• Molecular Weight: 2169.73 g/mol
• CAS Number: 514200-66-9
• PubChem CID: 16201427
• Purity: ≥95% (HPLC-verified)
• Storage: –20°C (long-term)

Applications

• Neuroinflammation research
• Multiple sclerosis models (EAE)
• Cognitive impairment and memory studies
• ApoE receptor pathway investigations
• Anti-inflammatory peptide drug development

Buy COG133 Peptide Online

Looking for high-purity COG133 ApoE mimetic peptide? We offer lab-tested, research-grade material ready for:

• Academic and pharmaceutical R&D
• Preclinical neuroimmune and cognitive health research
• In vitro and in vivo experiments

Buy COG133 peptide online today and support your next breakthrough in peptide-based neuroscience.