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COG1410, ApoE Mimetic Peptide

Regular price: $199.00 USD
Regular price: ~~$240.00 USD~~
Sale price: $199.00 USD

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Size 2 mg 10 mg

Description

COG1410 ApoE Mimetic Peptide | Neuroprotective & Anti-Inflammatory Research Peptide

Product Name: COG1410
Synonym: ApoE Mimetic Peptide
CAS Number: 878009-24-6
Molecular Formula: C₆₄H₁₂₁N₂₁O₁₄
Molecular Weight: 1408.78 g/mol
Sequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH₂
Purity: ≥98%
Appearance: Solid, white to off-white

What is COG1410?

COG1410 ApoE mimetic peptide is a synthetic peptide derived from the receptor-binding region of apolipoprotein E (ApoE). It is structurally enhanced with alpha-aminoisobutyric acid (Aib) residues for increased stability and bioactivity. This research peptide is known for its neuroprotective and anti-inflammatory effects, making it ideal for preclinical investigation into brain health, traumatic brain injury (TBI), stroke, and neurodegenerative diseases.

COG1410 Peptide Anti-Inflammatory Uses

● Neuroinflammation Reduction: COG1410 has demonstrated the ability to modulate inflammation in brain tissues following traumatic brain injury and ischemic events.

● Oxidative Stress Control: It reduces oxidative damage and cellular apoptosis in neuronal environments.

● Cognitive Recovery Support: Shows promise in improving neurological outcomes post-TBI in animal models.

● Immunomodulatory Effects: Helps balance pro- and anti-inflammatory cytokines in the central nervous system.

COG1410 for Brain Health Research

Used extensively in neurological research, COG1410 plays a key role in investigating:

● Traumatic Brain Injury (TBI)

● Cerebral ischemia and stroke

● Alzheimer’s and neurodegenerative conditions

● Neuroimmune interactions

Its design enables crossing of the blood-brain barrier, a vital feature for brain-targeted therapeutic research.

COG1410 vs COG112 Peptide Comparison

While both peptides are derived from ApoE and share anti-inflammatory and neuroprotective characteristics:

● COG112 includes a cell-penetrating peptide (CPP) sequence to enhance intracellular delivery.

● COG1410, with its Aib-modified backbone, offers increased resistance to enzymatic degradation and sustained bioactivity.

Researchers may choose COG1410 for longer-lasting effects and targeted action in neuroinflammatory models.

Storage & Handling

● Powder:

○ −80°C: 3 years

○ −20°C: 2 year

● In Solution (sealed, nitrogen-protected):

○ −80°C: 1 year

○ −20°C: 6 months

● Shipping: Room temperature (within continental US)

Specifications

Property	Value
Form	Solid
Color	White to off-white
Purity	>98%
Solubility	Soluble in water or buffer solutions
Application	Research use only (not for injection or human use)

Where to Buy COG1410 Peptide

Where to buy COG1410 peptide online? We provide high-purity, research-grade COG1410 ApoE mimetic peptide, available in bulk or small quantities for laboratories, universities, and R&D professionals. Ideal for formulations in brain injury, stroke, and neuroinflammation research.

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