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COG112, ApoE Mimetic Peptide

Regular price: $166.32 USD
Regular price: ~~$189.00 USD~~
Sale price: $166.32 USD

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size 2 mg 10 mg

Description

COG112 ApoE Mimetic Peptide | Anti-Inflammatory & Neuroprotective Research Peptide

Product Overview:

COG112 is a synthetic Apolipoprotein E (ApoE) mimetic peptide designed by conjugating the receptor-binding domain of ApoE (COG133) with the cell-penetrating peptide (CPP) antennapedia (Antp). This modification significantly enhances the peptide’s anti-inflammatory properties and neuroprotective effects compared to COG133 alone.

Sequence:

acetyl-YRQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-amide

Molecular Formula:

C₂₀₂H₃₄₇N₇₁O₃₈S₂

Molecular Weight:

4460.51 g/mol

Key Features and Uses:

● ApoE mimetic peptide COG112 is extensively studied for its ability to modulate inflammatory responses, primarily by inhibiting the NF-κB signaling pathway.

●Exhibits potent anti-inflammatory properties useful for research into neurodegenerative diseases and inflammatory bowel disease.

● Compared to the original ApoE peptide COG133, COG112 demonstrates enhanced cell penetration and therapeutic efficacy due to the CPP antennapedia conjugation.

● Recent research highlights the role of COG112 in cancer biology by inhibiting the SET-Rac1 interaction, resulting in decreased cancer cell migration and invasion.

● COG112 peptide is widely used in anti-inflammatory uses and ApoE peptide research studies to explore novel therapeutic applications.

Research Insights:

● COG112 vs COG133 ApoE peptide: The addition of the CPP domain in COG112 dramatically improves cellular uptake and anti-inflammatory activity compared to COG133 alone, making it a superior candidate for experimental therapies targeting inflammation and neuroprotection.

●Potential applications include modulation of inflammatory bowel disease, neurodegenerative disorders such as Alzheimer’s disease, and oncology research focused on tumor invasion and metastasis.

Product Applications:

Ideal for scientists and researchers investigating:

● Inflammatory signaling pathways (e.g., NF-κB inhibition)

● Neuroprotection mechanisms

● Cancer cell migration and invasion pathways

● Novel peptide therapeutics development

CAS #: NA

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