COG133, ApoE Mimetic Peptide

Regular price: $499.00 USD
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Sale price: $499.00 USD

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Description

COG133 ApoE Mimetic Peptide – Neuroprotective & Anti-Inflammatory Agent

COG133 is a synthetic ApoE mimetic peptide derived from the receptor-binding region of apolipoprotein E. It exhibits potent anti-inflammatory, neuroprotective, and cognitive-supportive effects, making it a key research peptide in neurodegenerative disease models and neuroimmune regulation.

COG133 Peptide for Cognitive Health

COG133 acts via the low-density lipoprotein receptor-related protein (LRP) pathway and demonstrates promising applications in neurobiology, especially:

Suppressing neuroinflammation
Reducing demyelination
Supporting cognitive resilience

In studies on experimental autoimmune encephalomyelitis (EAE)—a model of multiple sclerosis—COG133 significantly reduced clinical symptoms and spinal cord inflammation. This highlights its relevance for cognitive health and neuroinflammatory research.

COG133 Anti-Inflammatory Effects

Modulates CNS inflammation by targeting immune cell infiltration
Reduces pro-inflammatory cytokines, helping preserve myelin integrity
Shows activity as a non-competitive α7 nicotinic acetylcholine receptor antagonist with an IC₅₀ of 445 nM
Useful in inflammation-related neurological studies

COG133 vs COG112 Peptide Comparison

While both are derived from ApoE peptides, COG133 and COG112 differ in design and application:

COG133: LRP-dependent pathway, potent anti-inflammatory and cognitive protection
COG112: COG133 + penetratin sequence for improved BBB permeability
For applications not requiring direct CNS delivery, COG133 peptide offers a cleaner, focused mechanism of action.

Technical Specifications

Peptide Name: COG133
Sequence: Ac-LRVRLASHLRKLRKRLL-NH₂
Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉
Molecular Weight: 2169.73 g/mol
CAS Number: 514200-66-9
PubChem CID: 16201427
Purity: ≥95% (HPLC-verified)
Storage: –20°C (long-term)

Applications

Neuroinflammation research
Multiple sclerosis models (EAE)
Cognitive impairment and memory studies
ApoE receptor pathway investigations
Anti-inflammatory peptide drug development

Buy COG133 Peptide Online

Looking for high-purity COG133 ApoE mimetic peptide? We offer lab-tested, research-grade material ready for:

Academic and pharmaceutical R&D
Preclinical neuroimmune and cognitive health research
In vitro and in vivo experiments

Buy COG133 peptide online today and support your next breakthrough in peptide-based neuroscience.

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